In theory, yes you can choose any room in the house as the “safe room.” However, we strongly recommend bedrooms to be utilized as your FBS Sanctuary™.
Generally speaking, the time required to get to a “safe room” makes them impractical, especially if you were asleep when the intruder entered the home. They’d already have the element of surprise and you’ll be fighting through a haze of just waking up.
You’re most vulnerable when you’re asleep — when you’re unaware of what’s going on around you.
If your bedroom is already designated as your Sanctuary™, there won’t be any reason to wake up and rush to your “safe room.” You’re already in the safe room, and you can talk to the police from there.